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Content archived on 2024-05-27

Role of the ph-domain in regulating pdk1 activity

Objective

I propose to generate a PDK1 knocking mouse embryonic stem cell line that expresses a mutated form of DKP1 which PH-domain can not interact with PtdIns (3,4,5)P3. The study of this cell line will permit to further understand the mechanism by which PtdIns(3,4,5)P_3 regulates the insulin signal transduction

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Topic(s)

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Call for proposal

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Coordinator

UNIVERSITY OF DUNDEE
EU contribution
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Address
Nethergate
DD1 4HN DUNDEE
United Kingdom

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Total cost
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