Objective
This proposal aims to characterize the physiology and function of the long-TRP-channel LTRPC2 (TRPC7) in both normal physiological states and during neurodegeneration induced by metabolic stress. LTRPC2 is of particular interest because recent studies have demonstrated that the channel is permeable to calcium and activated by NAD^+, enabling the channel to sense the metabolic state of the cell and implicating this channel in mechanims of cell death. We will perform detailed investigations of channel physiology using recombinant cell lines expressing the human LTRPC2 channel. Electrophysiological characterization will be undertaken to study LTRPC2 channel properties with channel activation being confirmed using single cell imaging to enable direct measurement of intracellular free calcium levels to be made. Established 'array scan' cell death assays will be utilized to investigate the effects of LTRPC2 activation and potential modulators of this activity on cell signaling endpoints including MAP kinase and transcription factor activation states. This work will provide a fundamental insight into the functions of this important yet poorly characterized channel enabling us to test a novel hypothesis of cell death mechanism. The study of these channels may reveal exciting new therapeutic opportunities for neurodegenerative diseases such as Parkinson's and Alzheimer's disease. We aim to provide an extensive practical and theoretical neuroscience-training package to the research fellow. This will be enhanced by personal development plans offering a diverse range of excellent supplementary training courses covering general computing, communication skills and drug discovery. We will provide the fellows with a unique and exciting opportunity to undertake top quality research whilst gaining a comprehensive understanding of drug discovery in a top industrial environment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences cell biology cell signaling
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine neurology parkinson
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SG1 2NY STEVENAGE
United Kingdom
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