Objective
Linkage-disequilibrium (LD) mapping as a powerful tool for fine-mapping disease genes, the TSC have committed to produce a complete haplotype map of the human genome to enable large-scale LD mapping studies. The availability of this data set, calls for a unified tool for visualization of this haplotype data in the full genomic context, e.g. in relation to other SNPs, genes and other genomic information. No tools currently address the specific need to visualize haplotype data. This project proposes to develop tools to allow visualization and mining of haplotype data sets using Ensembl, a public genome visualization tool. All code generated, as part of this project will be contributed back to the public Ensembl project, in close collaboration with scientists at the EBI. In addition to developing tools to visualize haplotype data, we also propose to use the whole genome haplotype data set to perform a series of whole genome analyses to investigate the relationship between LD and physical and sequence-based properties of the genome. Large-scale genome analysis may be very informative, with a haplotype map as a reference it may be possible to estimate the extent of LD in a region based purely on human genome data, this ability may significantly enhance disease gene discovery. GSK bioinformatics has very substantial resources that will be fully available for use by the fellow. This includes access to modern powerful computing hardware suitable for studies of this scale. In addition to the academic and scientific aspects of this post. the fellow will have substantial personal development opportunities with full access to GSK training courses on IT skills, team working and personal development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TW8 9GS BRENTFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.