Objective
A key factor in the pathogenesis of several clinically important diseases is epithelial cell dysfunction. This proposal will investigate novel areas of epithelial cell biology with the aim of enhancing our understanding of the role of epithelial cells in the development and progression of chronic dermal wounds, COPD/asthma and endometriosis. Project 1 will investigate the role of retinoid receptor agonists on epithelial cell phenotype during dermal wound healing. The project will characterize retinoid receptor expression in primary human keratinocytes before and after mechanical injury. Subsequently, the study will investigate retinoid mediated gene expression in both in-vitro and in-vivo wound models. Project 2 will study the role of estrogen on endometrial cell function at a molecular level. This project will identify biomarkers of estrogen function in endometrium in-order to expand understanding of how estrogen mediated gene regulation impacts on endometrial estrogen response. Project 3 will investigate the responses of lung epithelial cells following allergen or bacterial challenge in-vitro. The project will identify changes in gene expression after exposure to house dust mite and H. influenzae, and investigate links with the release of key cytokines. Projects will employ state of the art micro-array technology (which is not available in most academic institutions) in-order to develop understanding of epithelial cell gene expression in a number of biological paradigms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- natural sciences biological sciences cell biology
- medical and health sciences health sciences infectious diseases RNA viruses influenza
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CT13 9NJ CANTERBURY
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.