Objective
Synthetic peptide vaccines are going to play a major role in the development of new therapeutic vaccines and an increasing role in preventive vaccines. Peptide vaccine development requires however screening of large sets of peptides to arrive at the desired peptide (or peptide like) antigen that can be used in the final vaccine. Because out of a vast amount of lead peptides, the ones that induce cross reaction with the target protein need to be selected, vast numbers of animal's tests are needed. This requires an enormous number of animals that must be kept during a very long time incurring tremendous cost. Effectively this blocks fast and systematic synthetic peptide vaccine developments. We propose to develop a new alternative procedure to select systematically out of a large set of candidate peptides the ones that induce the appropriate antibody response. This procedure is based on the assessment of specificity of antibodies that occur at a very early stage of the immune response against a peptide by measuring the emerging antibodies on antibody forming cells for their ability to bind the peptide (as expected) and the native protein (desired). Because this is key information that can be measured at an early stage, it will allow very early selection of the appropriate immunogen. Instead of months involving a few peptides the selection can be done in a few weeks involving many peptides; i.e. true high throughput vaccine development at fraction of the cost.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8203 AB LELYSTAD
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.