Glycosaminoglycans and their oligosaccharides derivatives : new opportunities in drug discovery.

Project Information

GLYCOSAMINOGLYCANS D

Grant agreement ID: HPMI-CT-2002-00201

Project closed

Start date 1 August 2002

End date 31 July 2006

Funded under

• Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002)

Total cost € 192 000,00

EU contribution € 192 000,00

Coordinated by

AVENTIS PHARMA RECHERCHE DEVELOPPEMENT S.A.
France

Objective

The Glycosaminoglycans are biological polymers, which plays key roles in numerous biological processes. Glycosaminoglycan is mainly represented by heparin, heparan sulfate, chondoitins ABC and hyaluronic acid. Their structural heterogeneity and complexity is mainly linked to their sulfation degree. From basic disaccharide repeating units to highly complex disaccharide arrangement in the heparin backbone, a world of infinite structural diversity and oligosaccharide sequence is encompassed. The most fascinating is undoubtedly heparin. Through a specific interaction with antithrombine III, this polysaccharide is able to inhibit proteases involved in coagulation cascade. However, heparin is also able to interact with many proteins and its now obvious that particular sequences mediates other biological process than haemostasis (i.e. angiogenesis). For example, heparin discrete domains promote or inhibit cells proliferation through FGFs interaction. Again, other parts of the macromolecule are able to inhibit so-called inflammatory processes. Our goal is to disconnect the different biological properties of heparin by synthesizing specific oligosaccharidic sequences. This concept is extended to the other GAGs like chondroitins. The postdoctoral fellows will have to address GAGs specific issues in hemi-synthesis / total synthesis in other to prepare the targeted oligosaccharides.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › chemical sciences › polymer sciences
• natural sciences › biological sciences › biochemistry › biomolecules › carbohydrates

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Programme(s)

• FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002)

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

BUR - Bursaries, grants, fellowships

Coordinator

AVENTIS PHARMA RECHERCHE DEVELOPPEMENT S.A.

• EU contribution: No data
• Address: Quai Jules Guesde 13 ; 94400 VITRY SUR SEINE ; France
• Total cost: No data