Objective
Crucells research training will involve the investigation of the possibilities to develop recombinant Ad35 as a vaccine delivery vehicle. The Vaccine Research Department will execute the following projects: a) Generation of a vector system and adenovirus packaging cell lines to produce high titered stocks of replication deficient Ad35 virus and subsequent in viva testing of efficacy and toxicity of these vectors, and b) investigation of the efficacy and safety profile of Ad5fib35 vectors in in vivo models (rodents, non-human primates). Although recombinant Ad35 is regarded as the vector of choice for vaccination it will be necessary to further investigate the Ad5fib35 chimeric vector because extensive knowledge, obtained in the past years in pre-clinical and clinical studies with Ad5-based vectors, is lacing for Ad35-based vectors, The advantage of Ad5Fib35 is that these vector can be efficiently produced at pharmaceutical scale with Crucells existing production technology. Safety, toxid, and efficacy studies with Ad5Fib35 will need to be executed to generate valuable information concerning the use of Ad35 based vectors in different vaccination programs. The general aim of this research project will be to develop antigens resulting in protection upon infection (prophylactic vaccination) or even eradication of diseased cells (therapeutic vaccination).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences zoology mammalogy primatology
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2301 CA LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.