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Nmr research infrastructure for paramagnetic biomolecules


The EC Large Scale Facility PARABIO, established in Florence in the new scientific Campus of the University, is part of the cluster of Research Infrastructures for Biomolecular NMR. The uniqueness of the infrastructure lies in the wide range of magnetic fields available, which allows a user to combine the two main NMR approaches, namely high resolution NMR and relaxometry. The infrastructure is equipped with an 800 MHz, two 700 MHz, one 600 MHz, one 500 MHz, one 400 MHz and one 200 MHz spectrometers. There are agreements to install a 900 MHz instrument as soon as it becomes available for us. A prototype 1H dedicated HP probe for the 800 MHz spectrometer developed under a RTD contract (FMGE-CT98-0107) and other specifically designed instrumentations are available to the Users.

The 500 MHz spectrometer is equipped with a Cryoprobe Ô. The 200 MHz NMR spectrometer is a wide-bore instrument and is equipped with MAS accessories. In addition to high field NMR spectrometers, PARABIO is equipped with several instruments to perform low-field NMR studies. A high resolution variable field instrument covers the 6-90MHz field range. A Field Cycling Relaxometer, operating in the 0.01-50 MHz range and a prototype Fast Field Cycling Relaxometer developed in the frame of an RTD contract (FMGE-CT95-0002), operating in the 0.001-20 MHz range, are available. With the EC support, we are working at the development of a High Sensitivity Fast Field Cycling NMR (HPRI-CT-2001-50028), that is expected to be available in one year.

Proposals to apply for access can be submitted continuously using the interactive application form found at proposed projects are evaluated by a local evaluation committee and by an "International User Selection panel". Successful applications will be granted access.
Project manager:
Prof. Ivano Bertini, Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino (Florence), Italy
Tel: +39-055-4574272
Fax: +39-055-4574271

Funding Scheme

LFC - Access to Research Infrastructures


Via L. Sacconi 6 C/o Università Di Firenze
50019 Firenze