Objective
The objective is to investigate the binding of metallo-supramolecular cylinders to DNA and to probe the remarkable structural effects induced by these cylindrical units with the goal of deliberately achieving such effects in a sequence-specific fashion. While DNA encodes the essential blueprint for life, within biological systems its structure and function is regulated by proteins. In the post genomic environment the goal is to understand the processing of the genetic code and how to stimulate or prevent this. Proteins frequently achieve DNA recognition via binding in or around its major groove since the size and shape of the major groove of B-DNA varies most with base sequence. Small synthetic recognition agents tend to target the minor groove or act via intercalation and often cause little or no bending of the DNA. Synthetic agents that target the major groove of DNA with recognition through non-covalent surface motifs have the potential to be a powerful new tool in the armoury of reagents that is being developed to tackle the post genomic challenge. Little progress has been made in this direction, due in large part to the size of the molecular surfaces required to achieve this. Supramolecular chemistry permits the design of large synthetic arrays, bridging the size-gap between small molecule and larger biomolecule DNA recognition-motifs. 3 partners in this proposal have described the DNA binding of a tetracationic supramolecular cylinder that is just the right size to fit into the major groove of DNA and too big for the minor groove (Angew. Chem., Intl. Ed., 2001, 40, 879-4). Excitingly this major groove-binding cylinder also induces a dramatic intramolecular bending effect resulting in coils of DNA that is unprecedented with a synthetic DNA binder. This proposal will develop and exploit these important findings. We will design and prepare synthetic metallo- supramolecular cylindrical major-groove recognition agents. We will investigate their
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CV4 7AL COVENTRY
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.