The results will consist of estimates of the risk of lung cancer in CCE/NIS by occupational medicine, air pollution and tobacco smoking.
The objectives of the projects are to identify occupational risk factors of lung cancer in Countries of Central Europe (CCE) and new Independent States (NIS), to quantify the contribution of occupational factors to the lung cancer burden.
The project will consist of an epidemiological case-control study, with data collection via personal interview and collection of blood and lung tissue samples. All incident cases of lung cancer in the selected areas or hospitals will be included. Controls will be selected among hospital patients undergoing minor surgical operations in the same hospitals as the cases. A detailed interview of each case and each control will be conduced either in the hospital or at home to elicit information on exposure to occupational agents and to other major known and suspected risk factors of lung cancer : tobacco smoking, passive smoking, dietary habits, residential history (to assess exposure to air pollution), family history of cancer, and personal history of X-rays and of diseases. Information on the clinical aspects of the neoplasms will be collected for cases only. Specific questionnaires will be used to elicit detailed information on job tasks and agents used in the case of employment in industries entailing exposure to known and suspected lung carcinogens. The study will be conducted in 6 areas from CCE/NIS characterized by high prevalence of industrialization.
The preliminary list of agents for which exposure will be assessed includes asbestos, arsenic, chromium, nickel, polycyclic aromatic hydrocarbons, formaldehyde, strong inorganic acids, man-made mineral fibers, wood dust, dust, gas and solvents.
No special measurements of air pollution will be made for this study, but existing data will be used to classify the current and historical exposures pertaining to the current and previous places of residence of each case and control.
Exposure to known and suspected occupational carcinogens will be assessed via an evaluation of the questionnaire responses by a team of experts (typically an industrial hygienist, chemist and occupational physician) set up in each participating center. This involves assessing level, probably duration of exposure to each agent, together with the confidence in the assessment, for each period of employment of each case and control.
Funding SchemeCSC - Cost-sharing contracts
WC1E 7HT London
975 56 Banska Bystrica
00 973 Warszawa
90 950 Lodz