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Occupation, environment and lung cancer in Central and Eastern Europe

Objective


Foreseen Results

The results will consist of estimates of the risk of lung cancer in CCE/NIS by occupational medicine, air pollution and tobacco smoking.
The objectives of the projects are to identify occupational risk factors of lung cancer in Countries of Central Europe (CCE) and new Independent States (NIS), to quantify the contribution of occupational factors to the lung cancer burden.

The project will consist of an epidemiological case-control study, with data collection via personal interview and collection of blood and lung tissue samples. All incident cases of lung cancer in the selected areas or hospitals will be included. Controls will be selected among hospital patients undergoing minor surgical operations in the same hospitals as the cases. A detailed interview of each case and each control will be conduced either in the hospital or at home to elicit information on exposure to occupational agents and to other major known and suspected risk factors of lung cancer : tobacco smoking, passive smoking, dietary habits, residential history (to assess exposure to air pollution), family history of cancer, and personal history of X-rays and of diseases. Information on the clinical aspects of the neoplasms will be collected for cases only. Specific questionnaires will be used to elicit detailed information on job tasks and agents used in the case of employment in industries entailing exposure to known and suspected lung carcinogens. The study will be conducted in 6 areas from CCE/NIS characterized by high prevalence of industrialization.

The preliminary list of agents for which exposure will be assessed includes asbestos, arsenic, chromium, nickel, polycyclic aromatic hydrocarbons, formaldehyde, strong inorganic acids, man-made mineral fibers, wood dust, dust, gas and solvents.

No special measurements of air pollution will be made for this study, but existing data will be used to classify the current and historical exposures pertaining to the current and previous places of residence of each case and control.

Exposure to known and suspected occupational carcinogens will be assessed via an evaluation of the questionnaire responses by a team of experts (typically an industrial hygienist, chemist and occupational physician) set up in each participating center. This involves assessing level, probably duration of exposure to each agent, together with the confidence in the assessment, for each period of employment of each case and control.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
Address
150,Cours Albert Thomas 150
69372 Lyon
France

Participants (7)

FODOR JOZSEF NATIONAL PUBLIC HEALTH CENTRE
Hungary
Address
2-6,Gyalli Ut 2-6
1966 Budapest
Institute of Hygiene, Public Health, Health Services and Management
Romania
Address
1-3,Dr. Leonte Street
76256 Bucharest
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
United Kingdom
Address
Keppel Street
WC1E 7HT London
N.N. Blokhin Cancer Research Centre -Russian Academy of Medical Sciences
Russia
Address
24,Kashirskoe Sh.
115478 Moskva
Specialized State Health Institute
Slovakia
Address
1,Cesta K. Nemocnici
975 56 Banska Bystrica
The Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology
Poland
Address

00 973 Warszawa
The Nofer Institute of Occupational Medicine
Poland
Address
8,Teresy Street
90 950 Lodz