Objective
Foreseen Results
The applied scientific goal of the proposed research is to help in identifying on a cost-benefit basis the most accurate and practical methods to assess hazardous occupational exposures.
The present proposal is aimed to evaluate the genetics effects of acrylonitrile in two occupational exposed populations from two plants (one in Portugal and one in Czech Republic). It involves 6 laboratories, 3 from EU-member states (Portugal, Belgium and United Kingdom) and 3 from Central Europe countries (Czech Republic, Slovakia and Hungary). Besides aiming the contribute to a better understanding of the hazardous exposure of man to acrylonitrile, it aims to help validating and optimizing the use of a combination of methods applied to human populations exposed to genotoxic compounds. Three main compartments related to the dose or effects of the hazardous compounds will be evaluated using various assessment methods :
Internal dose : mutagenicity in urine, indicators of oxidation stress, induction of cytochrome P450;
Biological effective dose : haemoglobin adduct, DNA excision products;
Early biological effects : chromosomal aberrations, sister chromatid exchanges, micronuclei and DNA damage (Comet assay).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences physical sciences astronomy planetary sciences comets
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1349-008 LISBOA
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.