Objetivo Foreseen ResultsThe applied scientific goal of the proposed research is to help in identifying on a cost-benefit basis the most accurate and practical methods to assess hazardous occupational exposures.The present proposal is aimed to evaluate the genetics effects of acrylonitrile in two occupational exposed populations from two plants (one in Portugal and one in Czech Republic). It involves 6 laboratories, 3 from EU-member states (Portugal, Belgium and United Kingdom) and 3 from Central Europe countries (Czech Republic, Slovakia and Hungary). Besides aiming the contribute to a better understanding of the hazardous exposure of man to acrylonitrile, it aims to help validating and optimizing the use of a combination of methods applied to human populations exposed to genotoxic compounds. Three main compartments related to the dose or effects of the hazardous compounds will be evaluated using various assessment methods :Internal dose : mutagenicity in urine, indicators of oxidation stress, induction of cytochrome P450;Biological effective dose : haemoglobin adduct, DNA excision products;Early biological effects : chromosomal aberrations, sister chromatid exchanges, micronuclei and DNA damage (Comet assay). Ámbito científico natural sciencesbiological sciencesgeneticsDNAnatural scienceschemical scienceselectrochemistryelectrolysisnatural sciencesphysical sciencesastronomyplanetary sciencescometssocial sciencespolitical sciencesgovernment systems Programa(s) FP4-INCO - Specific research, technological development and demonstration programme in the field of cooperation with third countries and international organizations, 1994-1998 Tema(s) 01020301 - Research into occupational medicine Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador UNIVERSIDADE NOVA DE LISBOA Aportación de la UE Sin datos Dirección 93,Rua da Junqueira 93 1349-008 LISBOA Portugal Ver en el mapa Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo 'Bela Johan' National Institute of Hygiene Hungría Aportación de la UE Sin datos Dirección 2-6,Gyali ut 1097 Budapest Ver en el mapa Coste total Sin datos INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Chequia Aportación de la UE Sin datos Dirección Videnska 1083 142 20 PRAHA 4 Ver en el mapa Coste total Sin datos MEDICAL RESEARCH COUNCIL Reino Unido Aportación de la UE Sin datos Dirección Lancaster Road University of Leicester Hodgkin Bui LE1 9HN Leicester Ver en el mapa Coste total Sin datos Prague Institute of Advanced Studies Chequia Aportación de la UE Sin datos Dirección 366,U Michelského Lesa 366 140 00 Praha 4 Ver en el mapa Coste total Sin datos UNIVERSITY P.J. SAFARIK Eslovaquia Aportación de la UE Sin datos Dirección 1,Tr.Snp 1 040 60 KOSICE Ver en el mapa Coste total Sin datos Université Catholique de Louvain Bélgica Aportación de la UE Sin datos Dirección 72,Avenue E. Mounier 1200 Bruxelles Ver en el mapa Coste total Sin datos
