Objective
* To investigate the nature of the reported absence of correlation between in vitro toxin neutralization assays and in vivo neutralization tests for diphtheria (and to a lesser extent tetanus) antibodies and to develop a practical solution for this phenomenon.
* To improve research and development capacity in vaccine quality control laboratories of public sector vaccine producers in two developing countries (Indonesia and Vietnam).
* To ensure quality in immunization programmes and local vaccine production by developing and making available scientifically validated test systems that can be used in developing countries.
Expected Outcome
* Understanding of the factors which have an effect on the mechanism of toxin neutralization.
* Recommendations to regulatory authorities on the selection and standardization of in vitro toxin neutralization tests.
* Research training to 2 Bio Farma and 2 IVAC staff workers for a period of 4 months each.
* The organization of a workshop on the immunological aspects of diphtheria toxin neutralization and antiserum production.
* Improved horse immunization schedules and the introduction of plasmaphoresis for the production of anti-D serum.
* Establisment of anti-diphtheria serumpanels from 4 different species
* Study of kinetics of neutralization test systems for diphtheria in in vitro tests (Vero cell test, ToBI, Double antigen ELISA, DELFIA) and in vivo tests (skin test in guinea pigs) using high, intermediate and low doses of toxin.
* Standardization of one or two selected in vitro toxin neutralization test systems, with established validity for the in vivo neutralization mechanism.
* Improve horse hyper-immunization schedules and introduction of plasmaphoresis.
* Provide research training to staff at RIVM (two from Vietnam and two from Indonesia) and implement/improve in vitro techniques in Vietnam and in Indonesia.
* Hold two project meetings: one at the onset of the project and one at mid-term, to upgrade research training.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology immunisation
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3720 BA Bilthoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.