Objective
* To identify the domain of VP4 interacting with sialic acids.
* To characterize the mechanism of membrane destabilization and pore formation.
* To determine the viral protein(s) and/or domain(s) responsible for membrane destabilization.
* To study the role of chaperones in folding and oligomerization of ET-associated proteins (VP7, NSP4).
* To elucidate the role of various genes implicated in early events of rotavirus infection.
Expected Outcome
* Insight in the mechanisms that allow penetration into the cell of large nucleoprotein complexes.
* New strategies for prevention of gastro-intestinal diseases.
* Scientific information exchange between scientists involved in the project in five countries.
* Exchange and dissemination of valuable reagents among the participant laboratories. Exchanges of methodology by short stays of scientists in the lab of another contractant.
* Organization of contractants meetings to produce relevant questions and methodology to answer them.
* Common preparation of publication in high standards journals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine gastroenterology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
78352 JOUY-EN-JOSAS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.