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Early events in rotavirus infection - role of viral proteins of particle internalization and membrane permeability

Objective

* To identify the domain of VP4 interacting with sialic acids.
* To characterize the mechanism of membrane destabilization and pore formation.
* To determine the viral protein(s) and/or domain(s) responsible for membrane destabilization.
* To study the role of chaperones in folding and oligomerization of ET-associated proteins (VP7, NSP4).
* To elucidate the role of various genes implicated in early events of rotavirus infection.
Expected Outcome

* Insight in the mechanisms that allow penetration into the cell of large nucleoprotein complexes.
* New strategies for prevention of gastro-intestinal diseases.
* Scientific information exchange between scientists involved in the project in five countries.
* Exchange and dissemination of valuable reagents among the participant laboratories. Exchanges of methodology by short stays of scientists in the lab of another contractant.
* Organization of contractants meetings to produce relevant questions and methodology to answer them.
* Common preparation of publication in high standards journals.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Address
Domaine De Vilvert
78352 Jouy-en-josas
France

Participants (6)

Institut National de la Santé et de la Recherche Médicale
France
Address
5,Rue Jean-baptiste Clément 5
92296 Chatenay-malabry
Instituto Venezolano de Investigaciones Cientòficas
Venezuela
Address
Carreterra Panamericana Km11
1020A Caracas
Instituto Venezolano de Investigaciones Cientòficas
Venezuela
Address
21827,
Caracas
Karolinska Institute
Sweden
Address
2,Lundagatan 2
105 21 Stockholm
Universidad De Santiago de Chile
Chile
Address
Alameda Bernado O'higgins
6500 Santiago
Universidad Nacional Autónoma de México
Mexico
Address

62250 Cuernavaca