Objective
* To establish the relationship between M.leprae infection and the development of immunity in a community in which multiple drug therapy (MDT) has been used for more than 10 years.
* To elucidate the pathogenesis of primary nasal infection in leprosy.
* To develop and test a chemotherapy-based intervention strategy for the interruption of leprosy transmission.
Expected Outcome
* Assessment of PCR positivity(putative infection) and immunity to leprosy in the endemic community.
* Whole population survey of 3 villages in India and one village in Africa. to obtain nasal swabs for polymer chain reaction(PCR) for M.leprae and specimens of saliva for measuring IgA levels against M.leprae.
* Child contact study. Samples will be obtained from 20 children from households with a treated leprosy patient and 20 controls at three monthly intervals over 3 years in 4 age groups.
* Assessment of immunity(IgA) and PCR positivity in newly exposed adults, with 3 monthly follow up over 3 years
* Assessment of the natural history of infection(PCR status) and immunity (Salivary IgA)in 30 adults identified in the MILEP1 study with 3 monthly follow-up.
* Development of simplified PCR and ELISA protocols (Miraj/AHRI/London/Bergen.
* ENT examination and nasal biopsy to be taken by an ENT surgeon of PCR positive individuals from village surveys which will be formalin fixed and sent to London for diagnosis and immuno-histo-chemistry for lymphocyte subsets in collaboration with Bergen.
Blood samples of PCR positive subjects to be obtained to determine cell mediated immunity(CMI)
* Double blind trial of single dose ofloxacin, rifampicin and minocycline in 60 new PCR positive subjects with monthly follow up for 6months and then 3 monthly measurement of PCR and salivary IgA to determine the course of infection.
* Intervention study to interrupt leprosy transmission. 'at risk' groups identified from activities 1-8 will be given a single dose of ofloxacin, rifampicin and minocycline with 3 monthly follow up.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
AB9 2ZD Aberdeen
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.