Objective
* To identify the sites where dormant bacilli survive, whether their metabolism is different from that of actively growing bacilli and whether they express different antigens.
* To study the nature of the immune response that maintains the latent state and differences between the immune response in men and mice and in latent and progressive tuberculosis.
* To define the immunological and endocrine factors which induce reactivation.
Expected Outcome
* A relevant mouse model for latent tuberculosis and reactivation of the disease in man. Knowledge of what antigens and biological mechanisms which induce keep-up and terminate latency and which are involved in reactivation of the disease.
* To strengthen research capability and training in two DC laboratories in tuberculosis high endemic countries.
* Establish a mouse model for asymptomatic lifelong infection with stable bacillary counts to study histopathology and number of bacilli throughout lungs, spleen, liver and bone narrow.
* Study antigen expression in actively dividing bacilli and in dormant bacilli through immune response to specific antigens, purification and characterisation and identification of gene activation.
* Study T-cell subsets and cytokines in various stages of tuberculosis infection in mice and men.
* Follow the antigen specificity of T-cell responses and antibodies throughout infection in men and mice.
* Study the importance of hormones, growth factors and non peptide biological active components from Mycobacterium tuberculosis in latency and reactivation of the disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine pneumology tuberculosis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
5021 BERGEN
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.