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A mouse model for latent tuberculosis and prevention of reactivatio n of the disease

Objective

* To identify the sites where dormant bacilli survive, whether their metabolism is different from that of actively growing bacilli and whether they express different antigens.
* To study the nature of the immune response that maintains the latent state and differences between the immune response in men and mice and in latent and progressive tuberculosis.
* To define the immunological and endocrine factors which induce reactivation.
Expected Outcome

* A relevant mouse model for latent tuberculosis and reactivation of the disease in man. Knowledge of what antigens and biological mechanisms which induce keep-up and terminate latency and which are involved in reactivation of the disease.
* To strengthen research capability and training in two DC laboratories in tuberculosis high endemic countries.
* Establish a mouse model for asymptomatic lifelong infection with stable bacillary counts to study histopathology and number of bacilli throughout lungs, spleen, liver and bone narrow.
* Study antigen expression in actively dividing bacilli and in dormant bacilli through immune response to specific antigens, purification and characterisation and identification of gene activation.
* Study T-cell subsets and cytokines in various stages of tuberculosis infection in mice and men.
* Follow the antigen specificity of T-cell responses and antibodies throughout infection in men and mice.
* Study the importance of hormones, growth factors and non peptide biological active components from Mycobacterium tuberculosis in latency and reactivation of the disease.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF BERGEN
Address
10,Armauer Hansen Building
5021 Bergen
Norway

Participants (4)

ARMAUER HANSEN RESEARCH INSTITUTE
Ethiopia
Address
1005
2003 Addis Abeba
Instituto Nacional de la Nutrición Salvador Zubiran
Mexico
Address
15,Calle Vasco De Quiroga 15
14000 Tlalpan Df
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
46 Cleveland Street
W1P 6DB London
University of Oslo
Norway
Address

0027 Oslo