Objective
Through the BIOMED1 programme, a grant was awarded for the co-ordination of Creutzfeldt-Jakob Disease (CJD) surveillance programmes in the European Union. National registries of CJD have been established in France, Italy, Germany, the Netherlands, Slovakia, Spain and the UK, and these project now share common diagnostic criteria and research methodologies. This harmonisation of projects has provided a unique framework to study putative risk factors for Creutzfeldt-Jakob disease, a disease of great potential public health and economic importance, following the occurrence of Bovine Spongifor Encephalopathy (BSE) and the description of a new variant of CJD which may potentially be causally linked to BSE.
The new objectives of the current proposal are:
1. To focus on the incidence of new variant CJD (NVCJD) in the EU and to analyse potential risk factors for this condition. Also to compare the incidence of NVCJD in Switzerland, a country with a low incidence of BSE and also in Canada and Australia, countries in which exposure to BSE is likely to have been minimal.
2. To study new diagnostic tests for CJD including CSF markers. 3. To provide material, including tissue samples, from well documented cases of CJD for other research projects in the EU, eg markers of infection in prion disease and transmission studies.
4. To develop educational material for relatives of patients and to provide information to the general public.
Continuing objectives are:
1. To study for trends in the incidence of CJD by the co-ordination of national registries of CJD in the EU.
2. To assess putative risk factors for CJD including past medical history, occupation, and diet.
3. To study the clinicopathological variants of CJD with reference to the influence of genetic and environmental factors on disease phenotype. 4. To study the molecular biology of CJD with specific reference to genetic factors that influence susceptibility to disease.
The proposed methodology of this proposal will be embedded in the previous BIOMED1 programme, although the objectives are focussed on BSE related exposures and new variant CJD. National registries have now been established in all participating countries and the aim of this concerted action is to continue with the harmonisation of these projects which will involve regular meetings of participating members and exchanges of staff.
KEYWORDS: Creutzfeldt-Jakob disease; national case registries; epidemiology; molecular biology; case-control study; educational tools.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Coordinator
EH4 2XU EDINBURGH
United Kingdom
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