Genetic profile of breast cancers in mediterranean countries: implications in preventive and predictive medicine

Objective

The BreastMed consortium will compare genetics of breast tumours at the clinical and molecular levels between 2 european and 3 mediterranean countries,considering different risk factors and clinical presentation heterogeneities. Germline BRCA1 and BRCA2 mutations will be sought, and molecular profiles of gene expression of a limited number of selected genes will be analysed in breast tumours by low-density cDNA chips. In 3 years, 750 tumours or patients (and their family if hereditary predisposition is suspected), will be recruited for the study. Better genetic counselling to breast cancer risk families, medical cares adaptated to the diagnosis of hereditary breast cancer risk or expression profiles of sporadic breast tumours, and standards for DNA chips manufacturing and comparisons are the main expected results of the consortium.

Fields of science

• natural sciences › biological sciences › genetics › DNA
• medical and health sciences › clinical medicine › oncology › breast cancer
• natural sciences › biological sciences › genetics › mutation

Programme(s)

• FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE JEAN PERRIN

Address

Rue Montalembert 58
63011 Clermont-ferrand
France

Participants (6)

FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR

Belgium

Address

61,rue De Bruxelles 61
5000 Namur / Namen

INSTITUT NATIONAL D'ONCOLOGIE SIDI MED BEN ABDELLAH

Morocco

Address

Rue Allal El Fassi
10100 Rabat / Agdal

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

Address

52, Avenue E. Mounier, Tour Vesale 5220
1200 Bruxelles

UNIVERSITE DU CENTRE

Tunisia

Address

Rue Avicenne
5019 Monastir

UNIVERSITE LIBRE DE BRUXELLES

Belgium

Address

Rue Héger-bordet 1
1000 Bruxelles

UNIVERSITE SAINT-JOSEPH

Lebanon

Address

Damascus Street
1107 2180 Beirut