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Genetic profile of breast cancers in mediterranean countries: implications in preventive and predictive medicine

Objective

The BreastMed consortium will compare genetics of breast tumours at the clinical and molecular levels between 2 european and 3 mediterranean countries,considering different risk factors and clinical presentation heterogeneities. Germline BRCA1 and BRCA2 mutations will be sought, and molecular profiles of gene expression of a limited number of selected genes will be analysed in breast tumours by low-density cDNA chips. In 3 years, 750 tumours or patients (and their family if hereditary predisposition is suspected), will be recruited for the study. Better genetic counselling to breast cancer risk families, medical cares adaptated to the diagnosis of hereditary breast cancer risk or expression profiles of sporadic breast tumours, and standards for DNA chips manufacturing and comparisons are the main expected results of the consortium.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE JEAN PERRIN
Address
Rue Montalembert 58
63011 Clermont-ferrand
France

Participants (6)

FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR
Belgium
Address
61,Rue De Bruxelles 61
5000 Namur / Namen
INSTITUT NATIONAL D'ONCOLOGIE SIDI MED BEN ABDELLAH
Morocco
Address
Rue Allal El Fassi
10100 Rabat / Agdal
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Address
52, Avenue E. Mounier, Tour Vesale 5220
1200 Bruxelles
UNIVERSITE DU CENTRE
Tunisia
Address
Rue Avicenne
5019 Monastir
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Address
Rue Héger-bordet 1
1000 Bruxelles
UNIVERSITE SAINT-JOSEPH
Lebanon
Address
Damascus Street
1107 2180 Beirut