Objective Tuberculosis causes 2-3 million deaths/year. A more effective vaccine than BCG is required, but rational vaccine trials cannot be planned for two main reasons. First, although many mycobacterium antigens have been isolated, we do not know which ones to test in human trials. It is not possible to test them all. Secondly we do not know which mechanisms are crucial for killing M. tuberculosis in man, so we cannot rationally select an adjuvant, or plan short term pilot studies using surrogate markers of protection. VACSEL will therefore conduct longitudinal studies, in 3 geographically distinct African countries, of TB contacts who do or do not develop clinical disease, in order to identify ;i) the antigens,ii) the cytokine profile andiii) the markers of apoptosis, that correlate with protection so that rational design and testing of vaccines can begin. Fields of science medical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY COLLEGE LONDON EU contribution No data Address 46 Cleveland Street W1P 6DB LONDON United Kingdom See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all ARMAUER HANSEN RESEARCH INSTITUTE Ethiopia EU contribution No data Address 1005 2003 ADDIS ABEBA See on map Total cost No data MEDICAL RESEARCH COUNCIL The Gambia EU contribution No data Address Atlantic Road MRC Laboratories Fajara 20 BANJUL See on map Total cost No data STATENS SERUM INSTITUT Denmark EU contribution No data Address 5,Artillerivej 5 2300 KOEPENHAGEN See on map Total cost No data UNIVERSITY OF ZAMBIA Zambia EU contribution No data Address University Teaching Hospital "D" Block, Jaoaranda 10100 LUSAKA See on map Total cost No data
