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Evaluation of novel recombinant antigens as candidates for a vaccine against schistosomiasis mansoni

Objective

Knowledge of the immune mechanisms elicited in rodents and primates by the attenuated schistosome vaccine will form the basis of efforts to develop a recombinant antigen vaccine against Schist soma mansion. Construction of special cDNA libraries will assist in novel molecular biology approaches to clone and express the relevant membrane/secreted larval antigens. The protective potential of all recombinants will be tested in mice, and the most promising also in baboons. Studies on human populations will identify differences between resistant and susceptible individuals in their responses to the recombinants. The estimation of infection intensity by measurement of circulating antigen levels will be validated in the realistic baboon model, and the interaction of infection with vaccination will also be explored in the baboon providing information vital future human vaccine trials.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF YORK
Address
Heslington
YO1 5YW York
United Kingdom

Participants (5)

FUNDACAO OSWALDO CRUZ - MINISTERIO DA SAUDE
Brazil
Address
1715,Av. Augusto De Lima 1715
30190-002 Belo Horizonte
JUSTUS-LIEBIG-UNIVERSITY OF GIESSEN
Germany
Address
Friedrichstrasse 24
35392 Giessen
LEIDEN UNIVERSITY
Netherlands
Address
Wassenaarseweg 72
2333 AL Leiden
MAKERERE UNIVERSITY
Uganda
Address
Mulabo Hospital & Complex
Kampala
NATIONAL MUSEUMS OF KENYA
Kenya
Address
Ololua Forest ,Karen Road National Museum Of Keny
00403 Karen