Evaluation of novel recombinant antigens as candidates for a vaccine against schistosomiasis mansoni

Objective

Knowledge of the immune mechanisms elicited in rodents and primates by the attenuated schistosome vaccine will form the basis of efforts to develop a recombinant antigen vaccine against Schist soma mansion. Construction of special cDNA libraries will assist in novel molecular biology approaches to clone and express the relevant membrane/secreted larval antigens. The protective potential of all recombinants will be tested in mice, and the most promising also in baboons. Studies on human populations will identify differences between resistant and susceptible individuals in their responses to the recombinants. The estimation of infection intensity by measurement of circulating antigen levels will be validated in the realistic baboon model, and the interaction of infection with vaccination will also be explored in the baboon providing information vital future human vaccine trials.

Fields of science

• natural sciences › biological sciences › zoology › mammalogy › primatology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• natural sciences › biological sciences › molecular biology

Programme(s)

• FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF YORK

Address

Heslington
YO1 5YW York
United Kingdom

Participants (5)

FUNDACAO OSWALDO CRUZ - MINISTERIO DA SAUDE

Brazil

Address

1715,av. Augusto De Lima 1715
30190-002 Belo Horizonte

JUSTUS-LIEBIG-UNIVERSITY OF GIESSEN

Germany

Address

Friedrichstrasse 24
35392 Giessen

LEIDEN UNIVERSITY

Netherlands

Address

Wassenaarseweg 72
2333 AL Leiden

MAKERERE UNIVERSITY

Uganda

Address

Mulabo Hospital & Complex
Kampala

NATIONAL MUSEUMS OF KENYA

Kenya

Address

Ololua Forest ,Karen Road National Museum Of Keny
00403 Karen