Objective
Knowledge of the immune mechanisms elicited in rodents and primates by the attenuated schistosome vaccine will form the basis of efforts to develop a recombinant antigen vaccine against Schist soma mansion. Construction of special cDNA libraries will assist in novel molecular biology approaches to clone and express the relevant membrane/secreted larval antigens. The protective potential of all recombinants will be tested in mice, and the most promising also in baboons. Studies on human populations will identify differences between resistant and susceptible individuals in their responses to the recombinants. The estimation of infection intensity by measurement of circulating antigen levels will be validated in the realistic baboon model, and the interaction of infection with vaccination will also be explored in the baboon providing information vital future human vaccine trials.
Fields of science
Topic(s)
Data not availableCall for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
YO1 5YW York
United Kingdom