Objective
HIV infection is not always protective against super infection by a second strain, but little data is available on circumstances of super infection. We propose to investigate prevalence, incidence, virology, immunology, clinical, and social factors associated with super infection in a cohort of highly exposed bar workers (600) in rural Tanzania, where 3 HIV-1 subtypes co-circulate (A,C,D). Once enrolled by voluntary consent, social research on parameter of cohort and the community, regular STI treatment and health care, and counselling on HIV prevention will be delivered and blood and CVL collected every 3 months for 3 years. Our study will help to determine whether super infection can occur in the face of a fully developed immune response, will define its natural history and virology outcomes, including emergence of recombinants, and will provide a new and innovative approach to define correlates of protective immunity for vaccine development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- humanitieshistory and archaeologyhistory
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health sciencesbasic medicineimmunology
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
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Topic(s)
Data not availableCall for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
80802 MUENCHEN
Germany