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Efficacy of an 11-valent pneumococcal conjugate vaccine in preventing radiologically confirmed pneumonia in the philippines

Objective

The general objective of the research is to find an effective primary prevention for a significant fraction of serious acute respiratory infections (ARI), especially of severe ARI and related severe disease , in infants and children in developing countries . This will be achieved by studying the effectiveness of the 11-valet pneumococcal conjugate vaccine in preventing childhood pneumonia in the Philippines within a population-based randomised placebo-controlled , blinded study . Scientific questions., including transmission of pneumococci will be addressed in nested studies and a specific household carriage study in Bangladesh . The minimum sample size of 10 260 children to be enrolled within 3 years time is calculated on the basis of the primary hypothesis . An interim analysis is planned at end of 3rd year . The final results within 5 years will be directly applicable to countries in the South-East and East Asian region, and more widely to the large and growing number of developing countries with a moderate infant mortality rate of 40-60 /1 000 live births .

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NATIONAL PUBLIC HEALTH INSTITUTE
Address
166,Mannerheimintie 166
00300 Helsinki
Finland

Participants (5)

AVENTIS PASTEUR SA
France
Address
Avenue Pasteur 3
92430 Marnes-la-coquette
GONOSHASTHAYA KENDRA
Bangladesh
Address
Mirzanagar Savar Cantt
1344 Savar
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Norfolk Place
W2 1PG London
RESEARCH INSTITUTE FOR TROPICAL MEDICINE
Philippines
Address
Filinvest Corporate City
1770 Muntinlupa City
UNIVERSITY OF QUEENSLAND
Australia
Address
Herston Road Herston
4006 Brisbane