The general objective of the research is to find an effective primary prevention for a significant fraction of serious acute respiratory infections (ARI), especially of severe ARI and related severe disease , in infants and children in developing countries . This will be achieved by studying the effectiveness of the 11-valet pneumococcal conjugate vaccine in preventing childhood pneumonia in the Philippines within a population-based randomised placebo-controlled , blinded study . Scientific questions., including transmission of pneumococci will be addressed in nested studies and a specific household carriage study in Bangladesh . The minimum sample size of 10 260 children to be enrolled within 3 years time is calculated on the basis of the primary hypothesis . An interim analysis is planned at end of 3rd year . The final results within 5 years will be directly applicable to countries in the South-East and East Asian region, and more widely to the large and growing number of developing countries with a moderate infant mortality rate of 40-60 /1 000 live births .
Funding SchemeCSC - Cost-sharing contracts
W2 1PG London
1770 Muntinlupa City