Objective The aim of the project is to develop a subunit vaccine and novel life-cycle stage specific diagnostics for T. annulated. Protective immunity involves effectors directed at 3 life-cycle stages (sporozoite, merozoite & schizont). Using a novel delivery system six available secreted schizont antigens plus an existing sporozoite & merozoite surface antigen will be tested for protective capacity. Previously noted synergism in protection between the sporozoite & merozoitesurface antigen will be further evaluated. Additional secreted schizont antigens will be isolated. Analysis of the immune response to these antigens will drive the design of further protection trials as will the role of antigenic diversity. Rapid, simple fondant serological diagnostics will be developed & used for epidemiological analysis and to assess the efficacy of novel subunit and existing live vaccines. Fields of science medical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF YORK EU contribution No data Address Heslington YORK United Kingdom See on map Links Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all ADNAN MENDERES UNIVERSITY Türkiye EU contribution No data Address Isikli AYDIN See on map Total cost No data ECOLE NATIONALE DE MEDICINE VETERINAIRE Tunisia EU contribution No data Address 2020 SIDI THABET See on map Total cost No data INSTITUT PASTEUR DE TUNIS Tunisia EU contribution No data Address 13,Place Pasteur 13 1002 TUNIS See on map Total cost No data UNIVERSITY OF GLASGOW United Kingdom EU contribution No data Address Bearsden Road G61 1QH GLASGOW See on map Total cost No data UTRECHT UNIVERSITY Netherlands EU contribution No data Address Yalelaan 1 3584 CL UTRECHT See on map Total cost No data