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Development of molecular vaccines and diagnostics for the control of tropical theileriosis

Objective

The aim of the project is to develop a subunit vaccine and novel life-cycle stage specific diagnostics for T. annulated. Protective immunity involves effectors directed at 3 life-cycle stages (sporozoite, merozoite & schizont). Using a novel delivery system six available secreted schizont antigens plus an existing sporozoite & merozoite surface antigen will be tested for protective capacity. Previously noted synergism in protection between the sporozoite & merozoitesurface antigen will be further evaluated. Additional secreted schizont antigens will be isolated. Analysis of the immune response to these antigens will drive the design of further protection trials as will the role of antigenic diversity. Rapid, simple fondant serological diagnostics will be developed & used for epidemiological analysis and to assess the efficacy of novel subunit and existing live vaccines.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF YORK
Address
Heslington
York
United Kingdom

Participants (5)

ADNAN MENDERES UNIVERSITY
Turkey
Address
Isikli
Aydin
ECOLE NATIONALE DE MEDICINE VETERINAIRE
Tunisia
Address

2020 Sidi Thabet
INSTITUT PASTEUR DE TUNIS
Tunisia
Address
13,Place Pasteur 13
1002 Tunis
UNIVERSITY OF GLASGOW
United Kingdom
Address
Bearsden Road
G61 1QH Glasgow
UTRECHT UNIVERSITY
Netherlands
Address
Yalelaan 1
3584 CL Utrecht