Objectif
Infectious diseases are a major burden on agriculture in developing counties. Current vaccines are expensive and often ineffective. We aim to develop a live recombinant BCG (brig) multivaccine that protects against predominant ruminant parasitic diseases in Latin America. Vector/host system will be developed to deliver parasite antigens to the bovine immune system. Immunogenicity will be measured in mice and protective efficacy measured in cattle. The brig vaccine will be developed in a strain deleted for dominant antigens. In parallel, animmunodiagnostic will be developed that targets deleted antigens and thereby distinguishes brig vaccination from natural Mycobacterium bovid infection. A rBCG vaccine and compatible TB diagnostic will promote affordable control of ruminant disease in developing counties. The vaccine should be cheap, heat-stable and effective via a single inoculation, and thereby promote sustainable development.
Champ scientifique
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- agricultural sciencesagriculture, forestry, and fisheriesagriculture
- agricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry