Skip to main content

Molecular tools for monitoring emergence and spreading of drug resistance among natural populations of leishmania

Objective

Leishmaniasis is a severe health problem in DCs and Europe. Pentavalent antimonials (SbV)will remain the first line drug for the forthcoming years. Control is being challenged by increased SbV resistance. Our aim is to design molecular tools for detecting emergence and spreading of drug resistance in visceral and mucocutaneous leishmaniases. To achieve this, we will obtain samples from SbV susceptible and refractory patients (Nepal, Bolivia, Peru ), identify molecular modifications associated with SbV resistance in FIELD isolates, transfer this Knowledge into molecular tools for drug resistance diagnosis, and define the population structure of sensitive and resistant isolates for understanding the epidemiological dynamics of drug resistance. Outputs: collection of naturally resistant parasites, knowledge on natural mechanisms generating SbV resistance and its transmission, PCR tools for preventing therapeutic failure and guidelines for their use in epidemiological surveillance.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUTE OF TROPICAL MEDICINE PRINCE LEOPOLD
Address
155,Nationalestraat 155
2000 Anvers /Antwerpen
Belgium

Participants (5)

B.P. KOIRALA INSTITUTE OF HEALTH SCIENCES
Nepal
Address
Ramshah Road
Kathmandu
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
United Kingdom
Address
Keppel Street
London
UNIVERSIDAD MAYOR DE SAN SIMON
Bolivia
Address
Avenida Aniceto Arce 0371
Cochabamba
UNIVERSIDAD PERUANA CAYETANO HEREDIA
Peru
Address
Avda Honorio Delgado S/n
100 Lima
UNIVERSITY OF GENEVA
Switzerland
Address
Rue Micheli-du-crest 24
1211 Geneve