Molecular tools for monitoring emergence and spreading of drug resistance among natural populations of leishmania

Objective

Leishmaniasis is a severe health problem in DCs and Europe. Pentavalent antimonials (SbV)will remain the first line drug for the forthcoming years. Control is being challenged by increased SbV resistance. Our aim is to design molecular tools for detecting emergence and spreading of drug resistance in visceral and mucocutaneous leishmaniases. To achieve this, we will obtain samples from SbV susceptible and refractory patients (Nepal, Bolivia, Peru ), identify molecular modifications associated with SbV resistance in FIELD isolates, transfer this Knowledge into molecular tools for drug resistance diagnosis, and define the population structure of sensitive and resistant isolates for understanding the epidemiological dynamics of drug resistance. Outputs: collection of naturally resistant parasites, knowledge on natural mechanisms generating SbV resistance and its transmission, PCR tools for preventing therapeutic failure and guidelines for their use in epidemiological surveillance.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance

Programme(s)

• FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUTE OF TROPICAL MEDICINE PRINCE LEOPOLD

Address

155,nationalestraat 155
2000 Anvers /Antwerpen
Belgium

Participants (5)

B.P. KOIRALA INSTITUTE OF HEALTH SCIENCES

Nepal

Address

Ramshah Road
Kathmandu

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

United Kingdom

Address

Keppel Street
London

Links

UNIVERSIDAD MAYOR DE SAN SIMON

Bolivia

Address

Avenida Aniceto Arce 0371
Cochabamba

UNIVERSIDAD PERUANA CAYETANO HEREDIA

Peru

Address

Avda Honorio Delgado S/n
100 Lima

UNIVERSITY OF GENEVA

Switzerland

Address

Rue Micheli-du-crest 24
1211 Geneve