Objective
The main scientific objective is the development of synthesis strategies for the biologically active sesterterpene Manoalide and diheteroprostanoids with potent biological activity. Selective transformation of polyfunctional system of 3-substituted butenolides into key synthons and target substances constitute the basis of the scheme proposed for the synthesis of sesterterpene and prostanoids.
The construction of modified w-prostanoid chains will be realised on the basis of Michael type reaction of 3-alkylsubstituted butenolide derivatives with (E)-1-(trimethylsilyl)-2-alkylthio-(or amino)ethylenes. Synthesis of key building blocks includes the preparation of the 3-acyltetronic acids followed by selective reduction of the oxo-function (and double bond) of the 3-acylsubstituent of derivatives formed. The synthetic route to Manoalide includes the synthesis of precursors of the target sesterterpene from butenolides and the synthesis of key building blocks. Fundamental problems of the project are connected to the investigation of butenolide derivatives and their behaviour in new chemical transformations.
During the projected work new synthetic routes for two natural products and new potent, bioactive PG-diheteroanalogues will be developed and realised.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
30167 Hannover
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.