Objective
The primary objective of the present proposal is to study the fundamental mechanisms of the unidirectional rotation in the ATP synthase as well as the openings dynamics of a DNA double helix on the basis of available experimental results. The ATP synthase is one of the beautiful as well as one of the most unusual and important enzymes. This complex consists of the two portions: F0 (ab2c9-12) and F1 (a3b3gde) and the latter has been observed very recently to act as a rotary motor, the smallest known so far. The F1 portion (e.g. F1-ATPase) is the main object for the studies in the project and therefore the primary goal concerning this part of the proposal is to understand the mechanism of the rotation of the g-subunit in the ab-hexamer.
The modelling on the basis of ratchets using also the concept of the binding change mechanism (cooperative rotational catalysis) is expected to give rise to better understanding the physical basis of the directed rotation of the F1-ATPase. As a result, a new type of ratchet motions is expected to be involved for molecular motor modelling. Particular emphasis will be placed on the ratchet models considered in three dimensions where rectifying the Brownian motion occurs due to helical structure of biological macromolecules. For these purposes the simplest mechanical models will be suggested and constructed and new stochastic equations when, e.g. the friction is correlated with driving noise, are to be derived and studied both analytically and numerically. Rotational ratchet and torsional solitons are being studied extensively in acting filaments. New soliton models for the collective proton motion that rapidly transports protons along hydrogen-bonded chains are expected to be found in studying circular movements of an internal c-subunit ring with respect to the a-subunit in the F0 complex. The soliton modelling of the macromolecules with helical structure, mainly a DNA double helix, and the investigation of their dynamics will be done on the basis of our preliminary results and approaches. It is expected that the openings dynamics in a DNA double helix can be described in terms of non-topological solitons.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
412 96 Gothenburg
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.