Biomolecular motor mechanisms modelled by ratchets and solitons

Información del proyecto

Identificador del acuerdo de subvención: INTAS-1997-00368

Proyecto cerrado

Fecha de inicio 1 Enero 1999

Fecha de finalización 31 Diciembre 2001

Financiado con arreglo a

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Coste total

Sin datos

Aportación de la UE

€ 55 000,00

Coordinado por

Chalmers University of Technology
Sweden

Objetivo

The primary objective of the present proposal is to study the fundamental mechanisms of the unidirectional rotation in the ATP synthase as well as the openings dynamics of a DNA double helix on the basis of available experimental results. The ATP synthase is one of the beautiful as well as one of the most unusual and important enzymes. This complex consists of the two portions: F0 (ab2c9-12) and F1 (a3b3gde) and the latter has been observed very recently to act as a rotary motor, the smallest known so far. The F1 portion (e.g. F1-ATPase) is the main object for the studies in the project and therefore the primary goal concerning this part of the proposal is to understand the mechanism of the rotation of the g-subunit in the ab-hexamer.

The modelling on the basis of ratchets using also the concept of the binding change mechanism (cooperative rotational catalysis) is expected to give rise to better understanding the physical basis of the directed rotation of the F1-ATPase. As a result, a new type of ratchet motions is expected to be involved for molecular motor modelling. Particular emphasis will be placed on the ratchet models considered in three dimensions where rectifying the Brownian motion occurs due to helical structure of biological macromolecules. For these purposes the simplest mechanical models will be suggested and constructed and new stochastic equations when, e.g. the friction is correlated with driving noise, are to be derived and studied both analytically and numerically. Rotational ratchet and torsional solitons are being studied extensively in acting filaments. New soliton models for the collective proton motion that rapidly transports protons along hydrogen-bonded chains are expected to be found in studying circular movements of an internal c-subunit ring with respect to the a-subunit in the F0 complex. The soliton modelling of the macromolecules with helical structure, mainly a DNA double helix, and the investigation of their dynamics will be done on the basis of our preliminary results and approaches. It is expected that the openings dynamics in a DNA double helix can be described in terms of non-topological solitons.

Programa(s)

• IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Tema(s)

• 4 - Life Sciences
• INTAS - INTAS

Convocatoria de propuestas

Datos no disponibles

Régimen de financiación

Datos no disponibles

Coordinador

Chalmers University of Technology

• Aportación de la UE: Sin datos
• Dirección: Kemivagen 10 ; 412 96 Gothenburg ; Suecia
• Coste total: Sin datos

Participantes (3)

Institute for Problems of Physics and Technology

Rusia

• Aportación de la UE: Sin datos
• Dirección: 13/7 Prechistenka Street ; 119034 Moscow
• Coste total: Sin datos

National Academy of Sciences of Ukraine

Ucrania

• Aportación de la UE: Sin datos
• Dirección: 14-B Metrologichna Street ; 252143 Kiev
• Coste total: Sin datos

Technical University of Denmark

Dinamarca

• Aportación de la UE: Sin datos
• Dirección: Building 321 ; 2800 Lyngby
• Coste total: Sin datos