Objective
The programme bears on the development of enzyme electrodes using the hydrogenase enzyme to transfer electrons between the electrode and molecular hydrogen. The ultimate goal is the clean production of energy, in the form of either H2 or electricity, by combining electrochemistry with enzymatic reactions. A major objective will be the development of inexpensive and efficient hydrogenase electrodes for H2 production.
For this purpose, the strategies of biomolecular immobilization developed at Grenoble (team of Dr S. Cosnier) and Moscow (team of Dr A. Karyakin) will be compared in terms of retention of enzymatic activities and efficiency of the electrical wiring step. A strong synergy is expected through the complementary interactions between the Grenoble and Moscow teams. In particular, the association of the capability in the field of biosensor construction (Grenoble) with the competence in the field of bioelectrocatalysis and electrode surface treatment (Moscow) should lead to the development of powerful configurations of enzyme electrodes.
Three biological laboratories participate to the project. The three laboratories currently study the hydrogenase enzyme and H2 metabolism in phototrophs. They are used to exchange informations between them and to collaborate. The task of the biochemists and microbiologists of Pushchino (team of Dr N. A. Zorin) will be to furnish the hydrogenase enzyme to be immobilized onto the electrode and to select from natural strains the best hydrogenase proteins (with respect to stability towards O2, pH, temperature, and with high activity). New purification procedures will be tested to increase the yield of enzyme and the speed of the purification step. The molecular biologists (team of Dr P.M. Vignais, Grenoble and Dr P. Lindblad, Uppsala) will contribute to the identification of new hydrogenase genes in the photosynthetic bacteria and the cyanobacteria. They will construct deregulated mutant strains overproducing active hydrogenase, which will be grown in Pushchino in continuous cultures. Besides, in tight collaboration with the electrochemists, the molecular biologists will design new forms of hydrogenase protein so as to overcome the constraints due to the fabrication of an enzyme electrode. Thus, the functionalization of hydrogenase proteins will contribute to improve the electrical communication or to develop new attractive immobilization procedures.
Given the competence of the five participating groups, a competence which goes from the extraction of the hydrogenase protein to the electrical connection of the enzyme, an extremely fruitful symbiotic and synergistic collaboration is expected.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Funding Scheme
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Coordinator
38041 Grenoble Cedex 9
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.