Exploitable results
Compounds for the treatment of cancer by neutron capture therapy which have been synthesized include the known compound, Na2[B12H11SH] (BSH) for which a new synthesis has been developed. In addition, a number of new derivatives of the boron clusters [B12H12]2- and C2B10H12 with functional tumour-seeking groups have been synthesized. These have included
(I) phthalocyanine and rhodamine derivatives of [B12H12]2- ,
(ii) thiourea, thiol, selenocyanate, hydroxy and acyloxy derivatives of [B12H12]2-,
(iii) ether lipid and phosphonate derivatives of carborane,
(iv) carborane derivatives of porphyrins, aminoacids, and mercaptans. Seven of the prepared compounds have been the subject of biological investigations.
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