Novel higher carboranes and boranes: synthesis and applications for antitumour neutron capture therapy, and new materials

Informazioni relative al progetto

ID dell’accordo di sovvenzione: INTAS-93-0023

Progetto chiuso

Data di avvio 1 Ottobre 1994

Data di completamento 30 Settembre 1995

Finanziato da

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Costo totale € 0,00

Contributo UE € 40 000,00

Coordinato da

University of Strathclyde
United Kingdom

Exploitable results

Novel higher carboranes and boranes: synthesis and applications for antitumour neutron capture therapy, and new materials

Compounds for the treatment of cancer by neutron capture therapy which have been synthesized include the known compound, Na2[B12H11SH] (BSH) for which a new synthesis has been developed. In addition, a number of new derivatives of the boron clusters [B12H12]2- and C2B10H12 with functional tumour-seeking groups have been synthesized. These have included (I) phthalocyanine and rhodamine derivatives of [B12H12]2- , (ii) thiourea, thiol, selenocyanate, hydroxy and acyloxy derivatives of [B12H12]2-, (iii) ether lipid and phosphonate derivatives of carborane, (iv) carborane derivatives of porphyrins, aminoacids, and mercaptans. Seven of the prepared compounds have been the subject of biological investigations.