Objective
The first goal of this project is to evaluate the contribution of N* and P* donor stereocentres of aminophosphine ligands into stereodifferentiation taking place during enantioselective catalytic reactions such as cross-coupling and hydrosilation catalyzed by Pd, Ni, Rh or Ru complexes containing N*, P* or N*, P* -chiral ligands. In the course of N*, P*-chiral aminophosphine synthesis, the influence of asymmetric N* -donor atom of starting cyclopaladated or ortholithiated a- arylalkylamines on stereochemistry and of their reactions with various racemic organophosphorus compounds of general type R1R2PX will be compared. The close arrangement of stereogenic donor centres towards metal (the centre of reactivity) should provide efficient stereocontrol of all these processes.
The second objective will focus on catalysis using palladium catalysis in aqueous media. This aspect is of considerable industrial interest from an industrial viewpoint economy, safety and pollution viewpoints. This metal is widely used in fine organic synthesis.
Particular attention will be devoted to molecules of pharmaceutical interest with the goal of optimizing the biological activity through the selective synthesis of a single enantiomer.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.