CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Exploitable results
Several methods of selective Csp2-C and Csp2-heteroatom bonds formation have been developed, among which is the hydrophosphorilation of terminal alkynes leading to α-substituted vinylphosphonates. Their subsequent asymmetric Ru(II) catalyzed homogeneous hydrogenation provides a new practical procedure for the enetioselective synthesis of α-substituted ethylphosphonic acids and esters (phosphorous analogues of well known non-steroidal anti-inflammatory drugs naproxen and ibuprofen).
Arylation (SNAr and palladium-catalyzed cross-coupling) of wide range of substrates (carbanions, heterocycles, silylphosphines) have been studied. The products obtained are of interest as ligands for transition metal catalysis (secondary and tertiary P-chiral phosphines), potentially bioactive compounds (substituted α-arylmethylphosphonates) and organic sythons (1-N-arylated benzotriazoles). In each case the reaction conditions were found to obtain the high yield of the product.
The synthesis of several tetraphosphines with bis-phosphine chelating moieties was carried out using Pd-catalyzed cross-coupling reaction and Pd-complexes of these ligands were obtained.
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