Objective
This project will develop systems generating active radicals for biological and chemical applications. It is based on: studies of cobalt and rhodium complex catalysts producing active oxygen species via redox reactions involving 02; synthesis and investigation of pH-dependent organocobalt sources of carbon-centred free radicals; and preliminary data on the biological activities of these complexes.
The research includes the synthesis of relevant transition metal complexes; the study of their redox characteristics and interaction with redox agents; the search for their chemical applications, first of all as initiators of radical reactions; the screening complex catalysts most active in cleavage of nucleic acids; the design of site-specific nucleases composed of a complex and a targeting oligonucleotide; the investigation of their efficiency in the cleavage of an RNA-target; and the investigation of biological activities of the complexes in question.
Call for proposal
Data not availableFunding Scheme
Data not availableCoordinator
4 Dublin
Ireland