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Content archived on 2022-12-23

Synthetic water-borne, reversible gels : design, characterisation, application

Objective



Water-soluble polymers and hydrogels are important materials used in many areas and are especially important for applications in biology and medicine. A few of the water-borne polymers such as poly-N-isopropylacrylamide, ethylene-and propyleneoxide polymers, poly-N-vinylcaprolactam etc., are characterised by a unique property to precipitate, forming hydrogels, above certain critical temperatures which can vary over a wide range depending on the polymer structure. This property gives the possibility of obtaining a thermally induced control of systems such as diffusion, viscosity, adsorption and, in combination with biocompatibility of those polymers, makes them very perspective materials for immobilisation of enzymes, drugs and other biologically active compounds, living cells, matrices for bioseparation, bioanalytical and diagnostic systems, implants and wound therapy.

The aim of the study is to synthesise new non-toxic water-soluble polymers with carbochain and heterochain structures and to obtain thermally reversible gels on the basis of these polymers. The carbochain polymers to be studied will mainly be poly(N-viylamides) (PVA) as these materials seem to be advantageous for cell and enzyme compounds as well as for bioanalytical and diagnostic systems.

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Coordinator

Universiteit Gent
EU contribution
No data
Address
Krijgslaan 281
9000 Gent
Belgium

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Total cost

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Participants (5)

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