Objetivo
Binding of Ca2+ ions to intracellular target proteins controls a variety of important cell functions. The concentration of intracellular calcium acts as a second messenger. The processes that control the concentration of intracellular calcium are related in nerve, cardiac and vascular cells.
The Ca2+ regulation of the following molecular events will be studied: gene expression, cell growth, cell differentiation and ageing; cell respiration by Ca2+ control of oxidative phosphorylation in the mitochondria; Ca2+ activation of contraction by Ca2+ binding to troponinC or to calmodulin; Ca2+ control of cell excitability by Ca2+ binding to membrane channels; and neuronal plasticity through Ca2+ control of presynaptic neurotransmitter release.
The results will extend the present understanding of important molecular events in the cardiovascular and the central neuronal system.
Convocatoria de propuestas
Data not availableRégimen de financiación
Data not availableCoordinador
50924 Köln
Alemania