Objective
The first part of this project is directed to the structural study of a new family of presynaptic proteins cloned by CNRS. This new family of presynaptic proteins forms a glutamate neuroreceptor when expressed in vitro. Methods will include a construction of neuroreceptor when expressed in vitro; a construction of recombinant plasmids based on yeast expression vectors and purification of the proteins. Further crystallographic analysis of the protein structure will be performed at the Medical Research Council Centre in the United Kingdom.
The second part of the project is in line with previous studies performed at CNRS,France, and concerns the study of the promoter region of the gene coding for a neurotransmitter biosynthetic enzyme tyrosine hydroxylase (TH). The project will be directed to the cloning of neuronal transcription factors, which recognise specific sites of the TH promoter, by using a collection of yeast mutants and expression vectors. Secondly, the techniques developed at CNRS and at St. Petersburg University, will allow identification and isolation of different members of the multimetric protein complexes involved in TH promoter activity.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
91198 Gif-sur-Yvette
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.