Objective
Transmitter release is subject to a variety of modulatory influences. Since the elevated intraterminal concentration of Ca is a trigger signal for the release, the change in the activity of Ca channels may serve as one of the most effective mechanisms of such modulation. According to recent data this is really the case; numerous regulatory mechanisms are targeted on various types of Ca channels. Hippocampal formation is characterised by an exceptionally elaborated system of synaptic modulation.
Different approaches will be combined for its investigation: to study the temporal characteristics of hippocampal synaptic plasticity and compare them with the behaviour of various Ca channels in the pyramidal neurons (main topic for Frankfurt and Kiev); to detect Ca signal under different pharmacological influences (main topic for Liverpool and Kiev); to develop models of excitability of pyramidal neurons that will account for the interrelationship between changes in the intracellular Ca and plasticity properties (main topic for Moscow). The methods used will include various electrophysiological measurements and optical imaging of intracellular Ca.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
60528 Frankfurt am Main
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.