Objetivo The project will focus on the design and chemical synthesis of various new compounds (including 2',3'-dideoxynucleoside analogues, phosphonate derivatives thereof, acyclic nucleosides, anthracycline and streptonigrin derivatives, and quinoxalines), which will then be evaluated in Leuven for their antiviral and antitumor activity. A wide variety of viruses (including influenza and other respiratory viruses, herpes simplex virus, varicella-zoster virus, cytomegalovirus, human immunodeficiency virus and other retroviruses) and tumour such as leukemia, lymphoma, carcinoma, cell systems will be included in this project. In addition, a series of mutant viruses and tumour cell lines, for which the mutations and/or enzyme defects are well-characterised, will be included in the evaluation of the novel compounds to allow more insight into the molecular interaction of the test compounds with their target enzymes (proteins) and/or the metabolic pathways involved to convert the test compounds to their metabolically active form. The chemical part of the project will be carried out by the five NIS partners and in the U.K. the biological part will fall under the responsibility of th Leuven group. Programa(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Tema(s) 45 - Pharmacology Convocatoria de propuestas Data not available Régimen de financiación Data not available Coordinador Katholieke Universiteit Leuven Aportación de la UE Sin datos Dirección Minderbroedersstraat 10 3000 Leuven Bélgica Ver en el mapa Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Academy of Sciences of Belarus Bielorrusia Aportación de la UE Sin datos Dirección 220141 Minsk Ver en el mapa Coste total Sin datos Russian Academy of Sciences Rusia Aportación de la UE Sin datos Dirección 119867 Moscow Ver en el mapa Coste total Sin datos UNIVERSITY OF WALES CARDIFF Reino Unido Aportación de la UE Sin datos Dirección King Edward VII Avenue, Redwood Building CF10 3XF CARDIFF Ver en el mapa Coste total Sin datos Urals State Technical University Rusia Aportación de la UE Sin datos Dirección 620002 Yekaterinburg Ver en el mapa Coste total Sin datos Volgograd Medicinal Institute Rusia Aportación de la UE Sin datos Dirección 400066 Volgograd Ver en el mapa Coste total Sin datos
