Blood-biomaterial surface interaction and biocompatibility of artificial organ and assist devices

Project Information

Grant agreement ID: INTAS-94-3033

Project closed

Start date 1 June 1996

End date 31 May 1999

Funded under

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Total cost No data

EU contribution € 67 000,00

Coordinated by

University of Strathclyde
United Kingdom

Objective

Interaction of blood and tissues with the surface of biomaterials in artificial organs (polymers, active carbon) will be studied in vitro and in animal tests. Emphasis will be given to protein adsorption, cell adhesion, contact activation, complement system activation and factors altering these processes. Representative parameters for evaluation of biocompatibility of artificial materials will be selected and methods for modifying the surface of biomaterials to improve their biocompatibility will be developed.

To investigate the role of particular blood components in the blood-surface interaction, adsorbents with high affinity to certain proteins will be synthesised and applied for the extraction of corresponding substances from blood circulation.

The results of the experimental studies will be used for interpreting data obtained on patients, for biocompatibility assessment, and for the creation of biomaterials with high biocompatibility.

Programme(s)

• IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Topic(s)

• 43 - Physiology and Fundamental Medical Science

Call for proposal

Data not available

Funding Scheme

Data not available

Coordinator

University of Strathclyde

• EU contribution: No data
• Address: Wolfson Centre 106 Rottenrow ; G4 0NW Glasgow ; United Kingdom
• Total cost: No data

Participants (5)

National Academy of Sciences of Ukraine

Ukraine

• EU contribution: No data
• Address: Kiev
• Total cost: No data

Science Academy of Lower Austria

Austria

• EU contribution: No data
• Address: 3500 Krems on der Donau
• Total cost: No data

St. Orsola University Hospital

Italy

• EU contribution: No data
• Address: Via Giuseppe Massarenti 9 ; 40138 Bologna
• Total cost: No data

St. Petersburg Medical Advance Institute

Russia

• EU contribution: No data
• Address: 193015 St. Petersburg
• Total cost: No data

Tashkent Scientific Centre for Surgery

Uzbekistan

• EU contribution: No data
• Address: 700107 Tashkent
• Total cost: No data