Objective
It is now firmly established that antibodies can act as efficient catalysts. These catalytic antibodies (abzymes) are classically elicited by using transition state analogues as antigens. The Russian group participating in this project has pioneered an alternative idea, i.e. possible catalytic activity of anti-idiotypic antibodies, and has demonstrated the presence of natural catalytic autoantibodies in sera of patients with autoimmune diseases. On the other hand, the French group, also participating in this project, has demonstrated the possibility of eliciting catalytic anti-idiotypic antibodies as internal images of enzyme active sites used as antigens.
This project, a joint investigation, is devoted to the search for new variants of natural catalytic antibodies and their comparison with corresponding analogues elicited by the anti-idiotypic approach. The project includes the study of general principles of antibody mediated catalysis and cloning of selected antibody genes in order to model and analyse the three-dimensional structures of their variable domains.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Coordinator
60206 Compiègne
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.