Objective
Excitatory synaptic transmission in the central nervous system is mediated by glutamate receptors (GluR). In the hippocampus, the NMDA subtype of GluR provides a mechanism for Ca2+ entry into the neurons during synaptic activity, thereby triggering various forms of synaptic plasticity. However, the overstimulation of NMDA receptors leads to an excessive accumulation of intracellular Ca2+, resulting in neurotoxicity. The NMDA receptor has regulatory binding sites for glycine, poliamines, protons, Zn, Mg, and its activity can be modulated by a large number of drugs. Despite massive efforts devoted over the last few years to understand the mechanisms of NMDA receptor function, many important questions remain unclear.
This study will focus on the different modulatory binding sites of the NMDA receptor complex. Using electrophysiological, biochemical, pharmacological, and fluorometric approaches a study will be made of how binding of non-competitive agonists and antagonists influence the physiological function of NMDA receptors. First, the action of the drugs on freshly isolated rat hippocampal pyramidal neurons will be examined. The knowledge obtained will then be applied further to study the modulation of glutamatergic synaptic transmission in hippocampal slices. The study will enhance understanding of NMDA receptor function in the mammalian brain and will provide insight into the mechanisms which underlie learning and memory formation.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
66421 Homburg-Saar
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.