Objective
The objectives of the project involve an experimental and theoretical study of influence of the structural factors on the tautomeric equilibrium, kinetics and mechanism of the sigma-tropic tautomerism (including superfast) in mollar systems with oxygen cation-accepting centers. The work plan comprises the synthesis of a series of stituted benzoylacetones, 4-nitrosophenols, 3- fluoroindophenols, 3-fluorobenzaurins and their organometallic derivatives in the laboratory of Prof. D.N.Kravtsov at A.N.Nesmeyanov Institute of Organo- Element Compounds, Moscow, Russia where expertise allready is available.
After synthesis and characterization, the aroylacetones and their organometallic derivatives will be studied in detail in the NMR group at the Institute of Bioorganic Chemistry, Minsk, Belarus using temperature dependent 2D-NMR spectroscopy by 200 MHz NMR spectrometer. stituted 4-nitrosophenols, 3- fluoroindophenols, 3-fluorobenzaurins and their organometallic derivatives will be investigated at the laboratory of Prof. A.S.Peregudov using 400 MHz NMR spectrometer adapted for a registration of the heavy metal NMR spectra. Here in particular dynamic NMR spectroscopy methods are widely used to study of dynamic processes in molles. The sensitivity problems will be overcome by studies of NMR spectra in the laboratory of Prof. P.E. Hansen at Department of Life Sciences and Chemistry, Roskilde University, Roskilde, Denmark. The calculation of a wide range of mollar properties of the compounds and studies of diffusion and spectral editing will be made in the laboratory of Prof. J.C. Lindon, Department of Chemistry, Birkbeck College, University of London, London, England. The expertise for all stages of this project exists in the laboratories in Roskilde, London, Moscow and Minsk.
The results of the joint investigation will be discussed in terms of the tautomeric preference and mechanism of tautomerism for organic and organometallic compounds to improve understanding of underlying reasons of the structural features of the compounds and the pliarities of tautomeric mechanisms which may be of benefit in future studies in pharmacology, environment protection and salvage.
Topic(s)
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4000 Roskilde
Denmark