Objective
A major problem in biological sciences is the lack of correct evaluation of membrane surface potential which governs number of biological processes. The development of new fluorescent probes sensitive to biomembrane surface charge density and potential is suggested here on the basis of a new concept. Crown ether groups are located at the biomembrane surface and bind to metal cations, the activity of which is directly associated with the surface potential. Crown groups are coupled to a ketocyanine chromophore which respond to ion-binding to the crown by a shift in the fluorescence spectrum.
For this purpose six crowned ketocyanines will be synthesized and extensively studied. The method will be tested in model membranes, biomembranes and cells. Finally, the use of these probes in solid matrices and Langmuir-Blodget films for elabo- rating ion-sensing devices will also be investigated.
Fields of science (EuroSciVoc)
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
31062 Toulouse
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.