Objective
The research to be carried out aims to investigate the mechanisms by which cells can cope with such situations by adapting their repair capability and to define the factors which play a role in such adaptive responses. Earlier studies in the laboratory of one participant have shown that an adaptive response resulting in a reduction of genetic damage can be elicited also in unconditioned cells by means of a factor present in, or released by, cells subject to a conditioning irradiation. The experiments planned in the proposal presented will define more clearly the release of the transmissible factor with respect to dependence on time, doses of conditioning and challenge, the nature of the transmission - by substances released from pre-irradiated cells or direct contact between cells-, the nature of the factor - size and type molecule (macromolecular, protein) -, the role of the factor in the reaction to other agents (mutagens) and the possible significance in vivo - in people treated with radiation or living in areas of high radiation exposure This observation of a transmissible factor involved in eliciting an adaptive response has not yet been described by other laboratories and is of great importance not only for our understanding of the mechanisms of the adaptive response but, once this factor is isolated, might also be useful for preventive treatments to render persons to be exposed more resistent against damage and/or to recognise persons which had been exposed to conditioning circumstances in contaminated areas. Such basic research performed in cooperation with institutes in the European Union will develop expertise in two laboratories in Kazakhstan which now are already active in the field. This will help them to face the specific problems present in Kazakhstan and to study genetic damage and its reDairabilitv in DeoDIe livina in contaminated reGions..
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
1300 Lisbon
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.