Objective
Abnormalities of p53 tumor-suppressor are the most common molecular alterations known to date in tumor cells. It is generally believed that oncogenic potential of p53 changes is connected with inactivation of its normal function that leads to a loss of negative control of cell proliferation and genetic instability responsible for further accumulation of mutations determining tumor progression. Some data indicate however that along with the loss of some activities the p53 mutants gain a new activities not observed with the wild-type protein. The molecular basis for these gain-of-function activities of mutant p53 which also have oncogenic effects is yet unknown.
The present project is directed to the identification of wild-type p53 functions and p53-regulated signalling pathways involved in prevention of arising and/or accumulation of various genetic changes (chromosome breaks, heteroploidy, gene amplification) and growth of cells transformed by RAS and some other oncogenes. In addition experiments directed to the understanding the mechanisms underlying the gain-of-function activities of tumor-derived p53 mutants and their role in cell transformation will be performed.
The results of these studies will be published in International scientific journals.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
20251 Hamburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.