Objective
The project is devoted to building a comprehensive model of mammalian cell-cycle regulatory network in normal and pathological states. This model will be used to make computer-aided predictions of potential anticancer pharmacological agents for key target molecules. The following main objectives will be achieved during realisation of this project.
We will create a database on cell cycle specific and related genes that will include available information on micro array gene expression data, data on gene transcription and translation regulation, proteomics data, comparative genomic data, SNP and other gene diversity data as well as related clinical data.
We will Develop models of the structure of genomic regulatory regions controlling gene expression of the most important genes involved in cell cycle regulation and predict new genes in genome involved in the cell cycle regulatory network.
We will build a computer model of the core regulatory network of mammalian cell cycle. Analyse the structure and dynamic properties of the cell-cycle model, identify possible stationary states, investigate parametric stability of network, bifurcation analysis, identify the most critical components and parameters that can move system from one stationary state to another.
We will modelling the structural and parametric changes in cell cycle regulatory networks during normal process of cell differentiation and the perturbations that are observed in different pathological situations for example deregulated cell proliferation. Identification of the components responsible for such perturbations and Identification of targets and of mechanisms how cell cycle perturbations can be minimized and/or how cancer cells can de directed into apoptosis will be done.
Finally, using the most modern methods of chemoinformatics we will search for pharmacological agents that can influence the potential target molecules revealed by the modelling. We will do modelling of the prolonged effects of the influence of the proposed pharmacological agents on dynamics of cell-cycle.
Integrating all knowledge collected and obtained on the previous steps into the most comprehensive knowledge databasebase on mammalian cell cycle regulatory network will be performed during realisation of this project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
WOLFENBÜTTEL
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.