Objective
Detection of biological agents is critical in many fields related to public health, foods industry, environmental control, water management and clinical and diagnostic analysis. In these fields there is an important need for the development of biosensor systems with low cost, high sensitivity and specificity, ease to transport for in-situ measurements, short analysis time and simple operation (easy handling). All these demand for the development of micromachined devices based in magnetic immunoassay techniques. In this project, microcoils are proposed as inductive transducers for the development of very high sensitivity and low cost biosensor arrays for the above-mentioned wide range of applications. This requires a previous assessment step in order to validate the ability of standard Si micromachining technologies for the proposed devices. Detection of biological agents is critical in many fields related to public health, foods industry, environmental control, water management and clinical and diagnostic analysis. In these fields there is an important need for the development of biosensor systems with low cost, high sensitivity and specificity, ease to transport for in-situ measurements, short analysis time and simple operation (easy handling). All these demand for the development of micromachined devices based in magnetic immunoassay techniques. In this project, microcoils are proposed as inductive transducers for the development of very high sensitivity and low cost biosensor arrays for the above-mentioned wide range of applications. This requires a previous assessment step in order to validate the ability of standard Si micromachining technologies for the proposed devices.
OBJECTIVES
The main objective of this project is the development of micro-inductive Biosensor arrays in standard CMOS Si technology for very high sensitivity detection. These devices are to be integrated in compact systems characterised by their low cost, high sensitivity, simple use, in-situ measuring capability (portability), and easy handling. In a first assessment phase (phase I), the project proposes the development of an integrated inductive sensor with sensitivity to detection of 10 magnetic nanoparticles. At this level, the project is not aimed to the development of a specific biological application, but to the design, fabrication and validation of the magnetic sensor device as integrated transducer. The design of the system includes that of the electronic circuit for the inductance determination of the microcoil, which is critical to achieve the required sensitivity. In a second phase (phase II is the ongoing three years full research project), the optimisation of the devices for the design and development of higher performance integrated sensor arrays to be applied for the high sensitivity detection of a concrete biomolecule will be addressed.
DESCRIPTION OF WORK
The Phase I of the project (assessment phase) is structured in 4 main tasks: 1.Design of the integrated device: Devices will be simulated under conditions modelling the presence of magnetic particles in their nucleus, to determine the geometrical features of the inductance structure. This task will also include the study on the most suited materials for the coils. At a final step, a set of masks will be provided;
2.Technology: Fabrication of the devices will be made in the Clean Room facilities of partner CNM-CSIC using standard CMOS Si technology. Test structures will be integrated in the processed wafers for the validation of the different technology steps;
3.Design and implementation of electronic circuitry: This will be done in direct interaction with task 1, as the structure of the devices and their characteristics strongly condition the optimum signal detection and processing design. This will be done taking into account the characteristics of simplicity, flexibility and sensitivity (noise rejected) of the aimed system. At this stage, circuitry will be implemented in a discrete way;
4.Characterisation of devices: Detection of magnetic particles. At this task, the validation of the devices as inductive sensors will be addressed, determining the characteristics of the system (sensor + electronics) for detection of the magnetic nanoparticles. The proposed goal for this assessment phase is the fabrication of devices with sensitivity down to 10 magnetic nanoparticles.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- medical and health sciences health sciences public health
- social sciences sociology governance environmental governance
- engineering and technology nanotechnology nano-materials
- engineering and technology environmental engineering natural resources management water management
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08007 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.