Objective The ultimate goal is the development of a Total Chemical Analysis System (TAS) incorporating integrated biosensor arrays, for detection for clinical and industrial purposes. The initial objective is to design a new instrumental approach by producing a functional model for TAS. This model will combine miniaturised in-vivo sample microdialysis, ex-vivo sample transport and preparation using flow injection analysis and measurement using integrated biosensor technology for real-time measurement of clinically important analyses (particularly lactate/glucose). Critical biochemical parameters requiring in-vivo monitoring are lactate and glucose. Glucose is important in diabetes care and lactate in a broad range of clinical conditions especially during and post surgery. The project concentrates on lactate but the measurement procedures to be developed will have far wider applicability. The concept of in-vivo sampling by microdialysis and transport to an ex-vivo site for assay, facilitates the calibration of sensors in clinical usage. Once developed the microdialysis system in conjunction with sensors could also be used in biotechnology industrial process control and environmental fields. The functional model TAS, could form the basis for prototype production with the basis for commercialisation. Practical benefits to be derived from development of a miniaturised TAS include the ability to analyse samples having small volumes, increased speed of analysis and reduction in consumption of reagents which may be expensive and harmful to the environment. Fields of science engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorsmedical and health sciencesclinical medicinesurgerymedical and health sciencesclinical medicineendocrinologydiabetes Programme(s) FP3-MAT - Specific research and technological development programme (EEC) in the field of measurements and testing, 1990-1994 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator St. Vincents Hospital Address 7,elm park 10 Dublin 10 Ireland See on map EU contribution € 0,00 Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all Ciba-Geigy AG Switzerland EU contribution € 0,00 Address 4002 Basel See on map MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE Germany EU contribution € 0,00 Address Robert-roessle-strasse 10 13092 Berlin See on map Technische Universität Wien Austria EU contribution € 0,00 Address 27-29,gusshausstraße 1040 Wien See on map University College Dublin Ireland EU contribution € 0,00 Address Glasnevin 9 Dublin See on map
