Objective
The work aims at the development and construction of advanced laser desorption ionization mass spectrometry instrumentation with special emphasis on the analytical demands of molecular biology research and biotechnology.
The instrumental set-up will be modular with a basic configuration for routine molecular mass screening of biopolymers and mixtures thereof by matrix-assisted laser desorption ionization (MALDI) with high accuracy and sensitivity. Upgrading comprises an ion reflectron for improved mass resolution and mass accuracy emphasizing the capability to perform structural analysis of the analytes by analysis of metastable fragment ions (PSD : post-source-decay analysis) e.g. for peptide sequencing and glycoconjugate investigation. Upgrading furthermore includes the implementation of appropriate sample stages in order to couple MALDI-MS to routine liquid separation techniques, especially to (micro-)HPLC and capillary electrophoresis. Within the project, procedural protocols are to be developed both to improve the current performance of the MALDI technique with respect to reproducibility of preparations including tolerance against contaminants and shot-to-shot fluctuations and to adapt these protocols to the requirements of samples eluted from liquid chromatography.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences electrochemistry electrophoresis
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences physical sciences optics laser physics
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
48149 MUENSTER
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.